Ethics, Policy & Environment, Volume 14, Issue 3, Page 313-327, October 2011.

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The (...) animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions. (shrink)

The early calculus is a popular example of an inconsistent but fruitful scientific theory. This paper is concerned with the formalisation of reasoning processes based on this inconsistent theory. First it is shown how a formal reconstruction in terms of a sub-classical negation leads to triviality. This is followed by the evaluation of the chunk and permeate mechanism proposed by Brown and Priest in, 379–388, 2004) to obtain a non-trivial formalisation of the early infinitesimal calculus. Different shortcomings of this application (...) of C&P as an explication of inconsistency tolerant reasoning are pointed out, both conceptual and technical. To remedy these shortcomings, an adaptive logic is proposed that allows for conditional permeations of formulas under the assumption of consistency preservation. First the adaptive logic is defined and explained and thereafter it is demonstrated how this adaptive logic remedies the defects C&P suffered from. (shrink)

In dem vorliegenden Band werden Arbeiten zusammengefafh, die sich kritisch mit Fragen von aus dem Marxschen Ideologiebegriff abgeleiteten Gesellschaftstheorien ebenso befassen wie mit der Komplexitat des Marxschen Ideologiebegriffs selbst, den orthodox-marxistischen und den marxistisch-revisionistischen Ideologietheorien, ihrem Wandel, ihren politisch-ideologischen Funktionen in unterschiedlichen histo­ risch-gesellschaftlichen Beziigen und, nicht zuletzt, ihrer theoretisch-methodologi­ schen Verwendbarkeit fiir das Verstandnis von Geist und Geschichte einerseits, Poli­ tik und Gesellschaft andererseits. Die hier versammelten Studien sind in den Jahren von 1960 bis 1975 entstanden. Sie beruhen zum (...) Teil auf Vorarbeiten, die bis in die Jahre 1954/55 zuriickreichen. Zwei Arbeiten sind bisher unveroffentlicht: der Einleitungsaufsatz »Ideologie und Ideologiebegriff. Dberlegungen zu ihrer metatheoretischen und immanent-kriti­ schen Aufarbeitung« (S. XIII-XVIII u. 1-21) und die Abhandlung »Entwurf einer Typologie des Ideologiebegriffs« (S. 82-102); aIle anderen Arbeiten sind, an ver­ streuten Stellen, bereits erschienen. 1m Laufe des letzten Jahrzehnts hat sich die theoretische Position des Verfassers insofern geklart, als er heute bestimmte Perspektiven der Wissenssoziologie und der Ideologiekritik mit einem historisch-soziologisch orientierten Funktionalismus in seinen metatheoretischen, d. h. theoretischen und forschungspraktischen, Beziigen systematisch aufzuweisen sucht. Damit wird einmal versucht, die These von der hi­ storisch-sozialen Bedingtheit von Theoriebildungen praziser als in der alteren Wis­ senssoziologie zu begriinden und historisches BewuBtsein durch positive Forschung neu zu fundieren. Mit einem solchen Ansatz versucht der Verfasser zweitens, die Kluft zwischen normativ-praskriptiven und empirisch-deskriptiven Forschungsan­ satzen, die in den Sozialwissenschaften weiterhin besteht, zu iiberbriicken. (shrink)

Currently, many authors in public and academic discourse speak of an increasing „social divide“ that threatens social cohesion. There has been a broad discussion on social cohesion in social sciences ever since: Different conceptions could be ideally classified in a scheme with a more rational and a more emotional pole. I explore this tension by following an affective turn in conceptions of social cohesion. Therefore, I focus on the concept of solidarity as representing the rational model of cohesion and the (...) concept of affinity standing for the affective one. The affective turn brings about a twofold shift in the understanding of the central processes of social cohesion: from collectivity to connectivity and from rationality to affectivity. Still, this shift runs the danger of throwing out the baby with the bathwater. Cohesion must neither be understood as exclusively reyling upon on either rational or affective processes. I propose to overcome this dichotomy by employing Hemming´s concept of „affective solidarity“. Rationaliy and affectivity must be understood as being mutually effective, the former modulating the latter, the latter energizing the former. (shrink)

Zusammenfassung Die Sportgeographie als ein noch sehr junges Teilgebiet der Sportwissenschaft und der Geographie begann sich erst vor circa vier Jahrzehnten zu entfalten. Abgesehen von einigen Vorläufern nahm die Sportgeographie ihren eigentlichen Anfang in den 1970er und insbesondere in den 1980er Jahren. Für den internationalen Aufschwung sorgten seitdem vor allem Wissenschafder des englischsprachigen Kulturraumes, wo sich die Sportgeographie im Laufe der 1990er Jahre in der Vielzahl der so genannten Bindestrich-Wissenschaften etablierte. In der deutschsprachigen Geographie und Sportwissenschaft hingegen ist dieser Etablierungsprozess (...) soweit noch nicht vorangeschritten, wenngleich auch hier erste Schritte einer Institutionalisierung unternommen wurden. (shrink)

Die Teilhabe an der lateinischen res publica litterarum der frühneuzeitlichen Fakultäten und Universitäten wurde mittels gemeinsamer literarischer Ausdrucksformen reguliert - zuweilen in Gestalt feingeistiger philologischer Kontroverse, zuweilen als wüste Polemik oder tosender Jubel. In Fallstudien zu Humanisten aus drei Jahrhunderten geht der Band der Frage nach, wie kollegiale Beziehungen literarisch inszeniert und innerhalb der Gelehrtengemeinschaft instrumentalisiert wurden. Diskursregeln und Kommunikationsbedingungen kommen dabei ebenso zur Sprache wie die Anwendung literarischer Modelle aus antiker und nachantiker Invektive, Satire und Panegyrik.

The use of genetic engineering inagriculture has been the source of much debate. Todate, arguments have focused most strongly on thepotential human health risks, the flow of geneticmaterial to related species, and ecologicalconsequences. Little attention appears to have beengiven to a more fundamental concern, namely, who willbe the beneficiaries of this technology?Given the prevalence of chronic hunger and thestark economics of farming, it is arguable thatfarmers and the hungry should be the mainbeneficiaries of agricultural research. However, theapplication of genetic engineering (...) appears unlikely tobenefit either of these two groups. This technology islargely controlled by the private sector, and itscontinued development hinges on its profitability.Thus, the only likely beneficiaries of the applicationof genetic engineering in agriculture are companieswith the capacity to use it. (shrink)

To celebrate the 270th anniversary of the De Gruyter publishing house, the company is providing permanent open access to 270 selected treasures from the De Gruyter Book Archive. Titles will be made available to anyone, anywhere at any time that might be interested. The DGBA project seeks to digitize the entire backlist of titles published since 1749 to ensure that future generations have digital access to the high-quality primary sources that De Gruyter has published over the centuries.

Von der Antike bis in die Gegenwart. Verständlich und anschaulich geschrieben, führt der Klassiker durch die wichtigsten Stationen des philosophischen Denkens. Die 4. Auflage wurde um die philosophischen Entwicklungen seit den 1990er Jahren ergänzt. Dazu gehören u. a. Analytische Philosophie, Ethik, Virtuelle Realität, Philosophie der Gefühle und Philosophie als Lebensform. Eine Besonderheit ist das umfangreiche Kapitel über die Philosophie des Ostens: Indien, China, Japan.

This article argues for the value of working with conflicts in social practice as resources for collaboration, learning and development. The interest in conflicts in social practice is rooted in a preoccupation with social power relations and how to understand and analyse power relations from a subject-science perspective. Following this interest, a methodological framework, best described as a kind of ‘mobile ethnography’, is discussed and exemplified through an empirical example. A preliminary conceptual framework for understanding power as a capacity for (...) action is presented. The overarching ambition of the article is to consider what democratic collaboration and coexistence entails and how it might be supported conceptually and analytically by the notion of conflicts as heuristics for social inquiry and by the notion of power as a capacity for action and social participation. (shrink)

CASUS is an authoring system, which should enable physicians to produce problem-based computer learning programs with minimal technical effort and give them sound instructional support. The theoretical background of CASUS are constructivist approaches to learning and instruction, which deal mainly with the question, how to design problem-based learning environments. The paper presents the constructivist concept of CASUS and results of a forma-tive evaluation. Four authors were observed and interviewed while developing a learning case with CASUS. The evaluation pursued mainly the (...) question of which difficulties arise while producing a case with CASUS and which measures are necessary in order to improve the authoring system. Results show that with regard to technical aspects physicians can produce learning cases even without any special prior knowledge. There were far more problems with instructional aspects of the production of cases. Most of these difficulties were very specific to the content of the cases. Therefore, it seems that an appropriate way to design learning cases with high quality, is a cooperation between some authors with different expertise. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS new appreciation of his thought. The differences between thirteenth-century and Renaissance humanism complicate the problem, but a more accurate and sensitive understanding of Aquinas's thought is by no means impossible. It is high time that Protestants put the old division behind them, high time they reclaim this part of their heritage-and they can rightly claim Aquinas as part of their heritage, since he did live and work (...) in the context of a still undivided Christendom. He is one of the teachers we can ill afford to do without as we attempt to meet the challenges of our own day (p. 174).' Whether Professor Vos achieves this objective can only be judged by those to whom the work is primarily addressed. Many of the misperceptions pointed out can be traced to misuse of St. Thomas's works in the era when he was the mandated author for Roman Catholic studies in philosophy and theology. Those who value the genuine thought of St. Thomas and regret the continuation of these misrepresentations by so-called Catholic traditionalists will welcome the contribution made by this book. THOMAS c. O'BRIEN Chambersburg, Pennsylvania Christian Dogmatics. By CARL BRAATEN (editor), GERHARD 0. FORDE, PHILIP J. HEFNER, ROBERT \V. JENSEN (editor) HANS SCHWARZ, and PAUL R. SPONHEIM. Two Volumes. Philadelphia: Fortress Press, 1984, xxii + 569 (Vol. 1) and xvii+ 621 (Vol. 2). Recent years have seen the proliferation among American Protestants of a seemingly odd genre: group dogmatics. For whatever reason, the present generation of' systematic theologians has not produced a dogmatics or systematic theology text that the theology teachers of' America seem to be happy with. So, a variety of' groups have banded together to divide all theology into so many parts,and as a team produce a usable theology text. The best known of' these group texts is Christian Theology: An Introduction to its Traditions and Tasks, edited by Peter G. Hodgson and Robert H. King (Philadelphia: Fortress Press, 1982), but there have also been Methodist and Conservative Evangelical versions. Christian Dogmatics is the latest example of' the genre, and an ambitious one. While the authors are all teachers at American Lutheran seminaries, their audience is the entire Christian Church. Their goal is to produce a " complete dogmatics " which will serve as " a textbook in theological instruction and a resource for those who practice the arts of ministry." (!,xvii-xviii). The volumes are organized in twelve loci, where a locus is " a point at which the historic teachings and theological investigations of BOOK REVIEWS 153 the church are brought into focus" (I, xix) : Prolegomena to Christian Dogmatics (Braaten, 78 pp.), The Triune God (Jenson, 114 pp.), The Knowledge of God (Sponheim, 76 pp.), The Creation (Hefner, 94 pp.), Sin and Evil (Sponheim, 104 pp.), The Person of Jesus Christ (Braaten, 104 pp.), The Work of Christ (Forde, 100 pp.), The Holy Spirit (Jenson, 78 pp.), The Church (Hefner, 70 pp.), The Means of Grace (Schwarz and Jenson, 142 pp.), Christian Life (Forde, 80 pp), and Eschatology (Schwarz, 116 pp.). Each locus consists of 4 to 7 chapters, each chapter beginning with a few summarizing sentences. The authors sometimes organize the loci "systematically" (e.g., the knowledge of God is organized according to questions that parallel Aristotle's four causes); more often the author's combine the systematic and the historical, moving through Seriptures and tradition and modernity as well as providing a conceptual frame for their topic. A lengthy index of names and subjects in volume two (II,591-621) helps the reader track the overlap between these loci. A variety of threads tie the disparate contributions together. The six authors share a common outlook on contemporary theology, which might be called a theological version of "the radical middle." Decisive for this outlook is the conviction that there is a doctrinal core to the faith which it is the central task of dogmatics to explicate (I,5). Although the problems and conceptualities of the modern world are addressed throughout the text, they are not allowed to set the interpretative agenda. In keeping their eyes fixed on this interpretative task, the authors avoid both the left and right. Liberation theology, process... (shrink)

During the past decade, several governmental reports have discussed how information technology can transform Danish society. Most important among these reports is Digital Denmark from 1999.In this article, the authors examine how to analyze Digital Denmark by considering two strategies for engaging reports. The first aims at uncovering and making explicit hidden assumptions or ideologies in the text. This approach is called “reading against the text.” The second approach—inspired by science, technology, and society studies—considers where a text goes and what (...) it does rather than how to critically interpret it. Texts may be read as material-semiotic actors, having effects on their environment that exceed or bypass discussions of content or motivation. This approach is called “reading with the text,” and the authors argue that traveling with Digital Denmark makes visible the limitations of critical analyses, while adding agency to the report as it moves in between practices. (shrink)

We offer a critical assessment of the “exclusion argument” against free will, which may be summarized by the slogan: “My brain made me do it, therefore I couldn't have been free”. While the exclusion argument has received much attention in debates about mental causation (“could my mental states ever cause my actions?”), it is seldom discussed in relation to free will. However, the argument informally underlies many neuroscientific discussions of free will, especially the claim that advances in neuroscience seriously challenge (...) our belief in free will. We introduce two distinct versions of the argument, discuss several unsuccessful responses to it, and then present our preferred response. This involves showing that a key premise – the “exclusion principle” – is false under what we take to be the most natural account of causation in the context of agency: the difference-making account. We finally revisit the debate about neuroscience and free will. (shrink)

It is often argued that higher-level special-science properties cannot be causally efficacious since the lower-level physical properties on which they supervene are doing all the causal work. This claim is usually derived from an exclusion principle stating that if a higher-level property F supervenes on a physical property F* that is causally sufficient for a property G, then F cannot cause G. We employ an account of causation as difference-making to show that the truth or falsity of this principle is (...) a contingent matter and derive necessary and sufficient conditions under which a version of it holds. We argue that one important instance of the principle, far from undermining non-reductive physicalism, actually supports the causal autonomy of certain higher-level properties. (shrink)

In this paper, we analyze what effects indicators of a shared situation have on a speaker’s persuasiveness by investigating how a robot’s advice is received when it indicates that it is sharing the situational context with its user. In our experiment, 80 participants interacted with a robot that referred to aspects of the shared context: Face tracking indicated that the robot saw the participant, incremental feedback suggested that the robot was following their actions, and comments about, and gestures towards, the (...) shared physical situation and linguistic references to the dialog history indicated to participants that the robot had learned from the interaction and perceived its surroundings. The results show that especially the linguistic and gestural references to the shared context have a significant influence on participants’ compliance with the robot’s suggestions. Thus, indicating that it is ‘in the same boat’ with the user, i.e. that it is sharing the situational context, increases a robot’s persuasiveness during advice giving. (shrink)

El liberalismo de Carlos S. Nino evolucionó desde sus primeros trabajos vinculados al derecho penal, hacia la construcción de una teoría de la democracia deliberativa. Desde sus comienzos, siguiendo a los autores liberales clásicos como John Stuart Mill, hasta el final en donde adhirió a un liberalismo igualitario, hubo construcciones que acompañaron este proceso, como el concepto de autonomía personal, y también ciertos ideales morales, como un oposición concreta al perfeccionismo. El texto presenta al liberalismo de Nino al comienzo y (...) al final de su obra para mostrar que el antiperfeccionismo originado en el liberalismo clásico que servía de base para construir su concepción de la autonomía, se mantuvo inalterado durante todo este proceso de evolución dificultando la compatibilización de su teoría de la responsabilidad penal con su teoría de la democracia deliberativa, orientada hacia el liberalismo igualitario. (shrink)

De-domestication is the deliberate establishment of a population of domesticated animals or plants in the wild. In time, the population should be able to reproduce, becoming self-sustainable and incorporating 'wild' animals. Often de-domestication is part of a larger nature restoration scheme, aimed at creating landscapes anew, or re-creating former habitats. De-domestication is taken up in this paper because it both engages and raises questions about the major norms governing animals and nature. The debate here concerns whether animals undergoing de-domestication should (...) be looked upon as wild or non-wild and the effect this has on questions about how they should be treated. It also concerns the value of nature, and the kind and degree of nature management considered appropriate. The paper first describes actual de-domestication practices and considers the character of human duties to animals in process of de-domestication. Secondly, the paper explores the implications of de-domestication for nature management, focusing on notions of naturalness and wildness. Finally, because the current division of ethical topics, with its dependence upon whether animals and nature are domesticated, hampers rather than helps, a new perspective is offered on the issues raised by de-domestication. More 'thinking outside the box' with regard to animals and nature is recommended. (shrink)

The systems studied in the special sciences are often said to be causally autonomous, in the sense that their higher-level properties have causal powers that are independent of the causal powers of their more basic physical properties. This view was espoused by the British emergentists, who claimed that systems achieving a certain level of organizational complexity have distinctive causal powers that emerge from their constituent elements but do not derive from them. More recently, non-reductive physicalists have espoused a similar view (...) about the causal autonomy of special-science properties. They argue that since these properties can typically have multiple physical realizations, they are not identical to physical properties, and further they possess causal powers that differ from those of their physical realisers. Despite the orthodoxy of this view, it is hard to find a clear exposition of its meaning or a defence of it in terms of a well-motivated account of causation. In this paper, we aim to address this gap in the literature by clarifying what is implied by the doctrine of the causal autonomy of special-science properties and by defending the doctrine using a prominent theory of causation from the philosophy of science. (shrink)